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Safety evaluation of microbial pesticide (HaNPV) based on PCR method

Miao Zhao, Shufei Li, Qinghong Zhou, Dianming Zhou, Ning He, Zhiyong Qian

Frontiers of Chemical Science and Engineering 2019, Volume 13, Issue 2,   Pages 377-384 doi: 10.1007/s11705-018-1777-9

Abstract: organs of animals; also indicate that the test subjects are not infectious to experimental rats after intravenousinjection of HaNPV.

Keywords： microbial pesticides     HaNPV     acute intravenous injection     infectivity     pathogenicity    

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A randomized, controlled, open label non-inferiority trial of intravenous ferric carboxymaltose versus

Frontiers of Medicine doi: 10.1007/s11684-023-1001-2

Abstract: Iron deficiency (ID) and ID anemia (IDA) pose significant public health concerns in China. Although iron sucrose (IS) treatment is well-established in the country, ferric carboxymaltose (FCM) offers the advantage of higher doses and fewer infusions. This open label, randomized, controlled, non-inferiority trial was conducted at multiple sites in China to compare the outcomes of FCM (maximum of 2 doses, 500 or 1000 mg iron) and IS (up to 11 infusions, 200 mg iron) treatments in subjects with IDA. The primary endpoint was the achievement of hemoglobin (Hb) response (an increase of ≥2 g/dL from baseline) within 8 weeks, whereas secondary endpoints included changes in Hb, transferrin saturation, and serum ferritin levels. Among the 371 randomized subjects, a similar percentage of subjects treated with FCM and IS achieved Hb-response (FCM 99.4%, IS 98.3%), thereby confirming the non-inferiority of FCM compared with IS (difference 1.12 (−2.15, 4.71; 95% confidence interval (CI))). Furthermore, a significantly higher proportion of FCM-treated subjects achieved early Hb-response at Week 2 (FCM 85.2%, IS 73.2%; difference 12.1 (3.31, 20.65; 95% CI)). Additionally, the increase in TSAT and serum ferritin levels from baseline was significantly greater at all time points for FCM-treated subjects. The safety profiles of FCM and IS were comparable, with the exception of transient hypophosphatemia and pyrexia, which are consistent with FCM’s known safety profile. In conclusion, FCM proves to be an efficacious treatment for IDA, providing faster Hb-response and correction of ID with fewer administrations than IS.

Keywords： iron deficiency     anemia     intravenous iron     ferric carboxymaltose     iron sucrose     Hb response     early response    

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A novel intravenous general anesthetic--- emulsified isoflurane: from bench to bedside

Cheng Zhou, Jin Liu

Frontiers of Medicine 2012, Volume 6, Issue 4,   Pages 381-387 doi: 10.1007/s11684-012-0229-z

Abstract: Emulsified isoflurane, the emulsion of isoflurane, is a novel intravenous general anesthetic.With the development of emulsified isoflurane in the past fifteen years, its utility has spread from intravenous

Keywords： emulsified isoflurane (EI)     general anesthesia     regional anesthesia     organ protection     anesthetic pharmacological study    

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Three-dimensional numerical simulation for plastic injection-compression molding

Yun ZHANG, Wenjie YU, Junjie LIANG, Jianlin LANG, Dequn LI

Frontiers of Mechanical Engineering 2018, Volume 13, Issue 1,   Pages 74-84 doi: 10.1007/s11465-018-0490-1

Abstract:

Compared with conventional injection molding, injection-compression molding can mold optical partsIn this study, a 3D simulation method was developed for injection-compression molding.in the cavity were investigated by using the proposed simulation method and compared with those of injectionpressures at different points along the flow path is complicated rather than monotonically decreased in injection

Keywords： injection-compression molding     simulation     injection molding     melt flow     cavity pressure    

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Fludarabine and intravenous busulfan conditioning with post-transplantation cyclophosphamide for allogeneic

Ling Wang, Lining Wang, Xing Fan, Wei Tang, Jiong Hu

Frontiers of Medicine 2021, Volume 15, Issue 1,   Pages 108-115 doi: 10.1007/s11684-019-0730-8

Abstract: neutrophil engraftment rate was 100%, and the overall incidence of grade II to IV and grade III to IV acutecould significantly reduce the incidence of chronic GVHD and its moderate to severe forms but not of acute

Keywords： post-transplantation cyclophosphamide     allogeneic hematopoietic stem cell transplantation     lymphoid malignancies    

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density measurement for plastic injection molding via ultrasonic technology

Frontiers of Mechanical Engineering 2022, Volume 17, Issue 4, doi: 10.1007/s11465-022-0714-2

Abstract: Density variation during the injection molding process directly reflects the state of plastic melt andExperiments with different process conditions are conducted, including different melt temperature, injectioni> measurement, non-destructive, high accuracy, low cost, and is of great application value for the injection

Keywords： ultrasonic measurement     melt density     in-situ measurement     injection molding    

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Economic Development Models of Gas Condensate Reservoir

Liu Tingyuan

Strategic Study of CAE 2001, Volume 3, Issue 3,   Pages 85-91

Abstract: condensate reservoirs, including reinjection with 75% dry gas recycling, dumpflooding of gas, nitrogen injection, water injection, water and gas alternating injection, C〇2 injection, etc.

Keywords： gas condensate reservoir     development model     gas injection     nitrogen injection     water injection     CO 2 injection     economic    

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Trend prediction technology of condition maintenance for large water injection units

Xiaoli XU, Sanpeng DENG

Frontiers of Mechanical Engineering 2010, Volume 5, Issue 2,   Pages 171-175 doi: 10.1007/s11465-009-0091-0

Abstract: Large-sized water injection units are key equipment in oilfields.maintenance costs, trend prediction technology is studied to achieve condition-based maintenance for water injectionproposed trend prediction technology can reflect the operating condition trend change of the water injection

Keywords： water injection units     condition-based maintenance     trend prediction    

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Intelligent methods for the process parameter determination of plastic injection molding

Huang GAO, Yun ZHANG, Xundao ZHOU, Dequn LI

Frontiers of Mechanical Engineering 2018, Volume 13, Issue 1,   Pages 85-95 doi: 10.1007/s11465-018-0491-0

Abstract:

Injection molding is one of the most widely used material processing methods in producing plasticstudies and developments of the intelligent methods applied in the process parameter determination of injection

Keywords： injection molding     intelligent methods     process parameters     optimization    

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Molecular pathogenesis of acute myeloid leukemia: A diverse disease with new perspectives

Felicitas THOL, Arnold GANSER

Frontiers of Medicine 2010, Volume 4, Issue 4,   Pages 356-362 doi: 10.1007/s11684-010-0220-5

Abstract: Acute myeloid leukemia (AML) is a very heterogeneous neoplasm of the hematopoietic stem cell.

Keywords： acute myeloid leukemia     mutations     risk stratification    

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methodology for regulating fuel stratification and improving fuel economy of GCI mode via double main-injection

Frontiers in Energy 2023, Volume 17, Issue 5,   Pages 678-691 doi: 10.1007/s11708-022-0859-z

Abstract: regulating concentration stratification and promoting fuel-gas mixing by utilizing the double main-injectioninjected gasoline with an octane number of 82.7 to investigate the energy ratio between the two main-injectionHigh-load experiments were conducted using the DMI strategy and compared with the single main-injectionAt a 10 bar indicated mean effective pressure, increasing the main-injection-2 ratio (Rm-2) shortens the injection duration and increases the mean mixing time.

Keywords： gasoline compression ignition     injection strategy     fuel stratification     high efficiency     high load    

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CO, N, and CO/N mixed gas injection for enhanced shale gas recovery and CO geological storage

Frontiers in Energy 2023, Volume 17, Issue 3,   Pages 428-445 doi: 10.1007/s11708-023-0865-9

Abstract: For the core flooding tests, pure gas injection showed that the breakthrough time of CO2 was of CO2 gas injectionFor CO2/N2 mixed gas injection, with the increase of CO2 concentration of the pure CO2 gas injection

Keywords： shale gas     gas injection     competitive adsorption     enhanced shale gas recovery     CO2 geological    

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Precision medicine in acute lymphoblastic leukemia

Ching-Hon Pui

Frontiers of Medicine 2020, Volume 14, Issue 6,   Pages 689-700 doi: 10.1007/s11684-020-0759-8

Abstract: The cure rate of childhood acute lymphoblastic leukemia (ALL) has exceeded 90% in some contemporary clinical

Keywords： acute lymphoblastic leukemia     molecular therapeutics     targeted therapy     tyrosine kinase inhibitors     immunotherapy    

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Experimental study of stratified lean burn characteristics on a dual injection gasoline engine

Chun XIA, Tingyu ZHAO, Junhua FANG, Lei ZHU, Zhen HUANG

Frontiers in Energy 2022, Volume 16, Issue 6,   Pages 900-915 doi: 10.1007/s11708-021-0812-6

Abstract: In this study, dual injection stratified combustion mode is used to accelerate the burning rate of leanThe effects of engine control parameters such as the excess air coefficient (Lambda), direct injectionand DI timing on combustion, fuel consumption, gaseous emissions, and particulate emissions of a dual injectionThere exists a spark window for dual injection stratified lean burn mode, in which the spark timing hasThe dual injection stratified lean burn has a wide range of applications which can effectively reduce

Keywords： dual injection     stratified lean burn     gasoline engine     particulate matter emission     combustion analysis    

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Genomic and pharmacogenetic studies of childhood acute lymphoblastic leukemia

Ching-Hon Pui

Frontiers of Medicine 2015, Volume 9, Issue 1,   Pages 1-9 doi: 10.1007/s11684-015-0381-3

Abstract:

With the cure rate of childhood acute lymphoblastic leukemia (ALL) approaching 90%, further improvement

Keywords： pharmacogenomics     acute lymphoblastic leukemia     genomics     pharmacogenetics    

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Title Author Date Type Operation

Safety evaluation of microbial pesticide (HaNPV) based on PCR method

Miao Zhao, Shufei Li, Qinghong Zhou, Dianming Zhou, Ning He, Zhiyong Qian

Journal Article

A randomized, controlled, open label non-inferiority trial of intravenous ferric carboxymaltose versus

Journal Article

A novel intravenous general anesthetic--- emulsified isoflurane: from bench to bedside

Cheng Zhou, Jin Liu

Journal Article

Three-dimensional numerical simulation for plastic injection-compression molding

Yun ZHANG, Wenjie YU, Junjie LIANG, Jianlin LANG, Dequn LI

Journal Article

Fludarabine and intravenous busulfan conditioning with post-transplantation cyclophosphamide for allogeneic

Ling Wang, Lining Wang, Xing Fan, Wei Tang, Jiong Hu

Journal Article

density measurement for plastic injection molding via ultrasonic technology

Journal Article

Economic Development Models of Gas Condensate Reservoir

Liu Tingyuan

Journal Article

Trend prediction technology of condition maintenance for large water injection units

Xiaoli XU, Sanpeng DENG

Journal Article

Intelligent methods for the process parameter determination of plastic injection molding

Huang GAO, Yun ZHANG, Xundao ZHOU, Dequn LI

Journal Article

Molecular pathogenesis of acute myeloid leukemia: A diverse disease with new perspectives

Felicitas THOL, Arnold GANSER

Journal Article

methodology for regulating fuel stratification and improving fuel economy of GCI mode via double main-injection

Journal Article

CO, N, and CO/N mixed gas injection for enhanced shale gas recovery and CO geological storage

Journal Article

Precision medicine in acute lymphoblastic leukemia

Ching-Hon Pui

Journal Article

Experimental study of stratified lean burn characteristics on a dual injection gasoline engine

Chun XIA, Tingyu ZHAO, Junhua FANG, Lei ZHU, Zhen HUANG

Journal Article

Genomic and pharmacogenetic studies of childhood acute lymphoblastic leukemia

Ching-Hon Pui

Journal Article